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A small increase in the incidence of hepatocellular carcinoma in male mice given 75 mg/kg/day of bicalutamideapproximately 4 times human therapeutic concentrationsand an increased incidence of benign thyroid follicular cell adenomas in rats given 5 mg/kg/dayapproximately 2/3 human therapeutic concentrationsand above were recordedThese neoplastic changes were progressions of non-neoplastic changes related to hepatic enzyme induction observed in animal toxicity studiesEnzyme induction has not been observed following bicalutamide administration in manThere were no tumorigenic effects suggestive of genotoxic carcinogenesis.

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Inactive ingredientslactosemagnesium stearatehypromellosepolyethylene glycolpolyvidonesodium starch glycollatetitanium dioxide.

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casodex bicalutamide is a member of the antiandrogens drug class and is commonly used for prostate cancer.

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